Reported by: KE Xuan
Translated by: MIAO Siwei
Edited by: Armin Wisselink
Updated: 2012-6-8
March 19th, HIT’s research project The Preparation and Physicochemical Property Study of New Cell Membrane Mimetic Nanomaterial has been approved for funding by the National Science Foundation of Heilongjiang Province.
This research, applying nanotechnology, organic chemistry, molecular chemistry and biochemistry, designed a new type of organic/inorganic compound lipid, with which a highly stable organic/inorganic compound artificial cell nanoparticle was made.
The new nanoparticle has a surface covered with a layer of crosslinking siloxane reticulation whose thickness is similar to molecules, and can stay in aqueous solution for a few months. It not only maintains the essential properties of traditional bilayer membrane structure, but also keeps its full 3D vesicles in a solid base even with Triton X-100’s (a kind of compound that lowers the surface tension of a liquid, namely surfactants) influence. This nanoparticle has been reported as the world's most steady membrane structure.
The project, adopting layer-by-layer self-assembly, can integrate fluorescent dyes and various enzymes into artificial cell nanoparticles to detect nano liposomes in environmental pollutants. The layer-by-layer assembly method, which controls nanoparticles at the nanometer scale, thus improves detection sensitivity.
To date, 7 papers related to this project have been published, 4 of which are included in SCI (Science Citation Index) and 3 of which have resulted in patent applications.
The Chemical structural formula of composite liposomes
