Reported by: Liu Peixiang
Translated by: Sun Jianyao
Edited by: Garrick Jones
Integration research of tumor diagnosis and treatment has been the focus of the academic community. Recently, Professor Liu Shaoqin’s research group of the Micro and Nano Technology Research Center of HIT Institute of Basic and Interdisciplinary Science made the great progress in the field of tumor diagnosis and treatment integration. Their research PCsxWO3 Nanorods Coated with Polyelectrolyte Multilayers as a Multifunctional Nanomaterial for Bimodal Imaging-Guided Photothermal/Photodynamic Cancer Treatment was published in the internationally renowned academic journal Advanced Materials (impact factor 18.96). The first author of the article is PhD student Guo Wei in Life Science College 2014 , young teachers Guo Shenshu and Liu Shaoqin are the corresponding authors, and HIT is the only corresponding unit.
Tumor is one of the leading causes of death worldwide. Traditional radiotherapy and chemotherapy can destroy cancer cells while harming normal cells. Therefore, the current scientific community has been seeking less-disruptive treatment. Among them, photothermal therapy and photodynamic therapy cure the tumor tissue through near-infrared radiation. Photothermal treatment deliveries the photothermal agents to the tumor tissue contributing to the local photothermal ablation of the tumor. As for the photodynamic therapy, it relies on the free radicals of photosensitizer to eliminate the tumor.
Through the simple combination of multiple components, traditional diagnosis and treatment integration system have some shortcomings, for example, the mutual interference among the multiple components within the system, the complexity of the synthesis, and the disintegration of the system in process. Professor Liu Shaoqin’s research group use a single species to achieve a variety of functions, effectively avoiding the traditional medical treatment systems many shortcomings. They chose PCsxWO3 nanorods coated with polyelectrolyte multilayers as a multifunctional nanomaterial for bimodal imaging-guided photothermal/photodynamic cancer treatment which can both produce regional hyperthermia and free radicals under near-infrared radiation, contributing to double antitumous effects. Meanwhile, the light-thermal conversion efficiency and large atomic number of PCsxWO3 contributes to its X-ray computed tomography (CT) and photo acoustic imaging tomography (PAT) which make the visual monitor in the process of oncotherapy possible. The CsxWO3 NR@PEM system will open the avenue toward development of the simple but general solutions for future bioimaging and cancer treatment.
Link to the paper：http://onlinelibrary.wiley.com/doi/10.1002/adma.201604157/epdf
